Thursday, November 29, 2007


Science Now:
Paris Hilton: Actress, author, ... analgesic? Neuroscientists have found that a cardboard cutout of the ubiquitous Hilton Hotel heiress has a painkilling effect on mice. But don't expect clinical trials to begin anytime soon: Paris works only for males, and it may be only because she stresses them out.

The idea for the unconventional experiment arose when Jeffrey Mogil of McGill University in Montreal, Canada, and his colleagues noticed that male mice spent less time licking the site of a painful injection--indicating that they had less pain--when a scientist was present. To investigate whether it was the sight or smell of a human that caused the effect, the researchers acquired a promotional cardboard cutout of Hilton from her television show The Simple Life ("A special order," says Mogil's collaborator Leigh MacIntyre).

As in humans, Paris's effect appears to be gender-specific. Male mice spent less time licking their wounds when fake Paris was in sight, but females showed no such effect, the researchers reported here Saturday at the annual meeting of the Society for Neuroscience. When the team put up a screen to block the rodents' view, the effect went away. Following a Paris Hilton encounter, male mice--but not females--also had lower-than-usual expression of a gene called c-fos in a part of the spinal cord that transmits pain signals to the brain, suggesting reduced neural activity in this pain pathway.

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